The most common medical ester is (ASA; acetyl salicylic acid). Other drugs such as Guard (anti-wormer), Maxicaine (), Malathion (organophosphate), (antihelmenthic), Demerol (narcotic analgesic) and Equinil () are also .
The starting for this experiment are salicylic acid and acetic anhydride (structures are shown above).

Salicylic acid reacts better with acetic anhydride than acetic acid, so acetic acid will provide the acetyl group which will react with the alcoholic -OH group on the salicylic acid. (The reaction is on the top of the post.)

needed for the reaction: Salicylic acid, Acetic anhydride, and Concentrated sulfuric acid.

Equipment: 250 , Hot , Ice bath, and filter paper, Glass stirring rod, and Electronic pan balance and weighing boat.


Let’s look at some :
One problem occurs with aspirin is that it has a on the and inhibit the of . To resolve this problem, we can use potential anti-platelet agents including the O-acyl which are synthesized from and . Those agents work by of and have a higher extraction than aspirin. That makes them yield a greater selectivity in their effect on platelet relative to prostacyclin on vessel walls.

The actual reaction is shown on the top.